LISA: does mild sedation increase the risk of intervention due to loss of respiratory drive? A systematic review

Less invasive surfactant administration (LISA) has become the preferred way to administer surfactant to neonates. However, discussion is still ongoing on whether sedation is required, particularly to preterm neonates. This paper is a review of the literature and evidence on sedation versus non-sedation for LISA.

Robyn Victoria Jones
MSc University of Southampton, Faculty of Health Sciences
robyn.jones5@nhs.net

Sarah Irwin
Clinical Teaching Fellow, University of Southampton

Jones R.V., Irwin S. LISA: does mild sedation increase the risk of intervention due to loss of respiratory drive? A systematic review. Infant 2024; 20(3): 124-28.

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Keywords

neonates; respiratory distress; RDS; less invasive; LISA; sedation

Key points

There are no current guidelines on the use of sedation for LISA. As a result of sedation, preterm infants could become apnoeic, bradycardic, and may consequently require positive pressure ventilation.
Preterm infants administered sedation who become apnoeic, may require intubation and mechanical ventilation.

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VOLUME 20 ISSUE 2/MARCH 2024

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