Human milk oligosaccharides and necrotising enterocolitis
Human milk is known to reduce the risk of necrotising enterocolitis (NEC) in preterm infants, but mechanisms are poorly understood. Human milk oligosaccharides (HMOs) are complex sugars produced by the mammary gland and present in variable amounts in different breast milks. Animal models show HMOs impact on development of NEC and human
preterm infant studies show a specific HMO, called
disialyllacto-N-tetraose (DSLNT), is present in maternal milk in lower amounts in infants who go on to develop NEC. This article reviews the role of HMOs in NEC development and the clinical data in preterm infants, and considers the possible next steps for supplementation in preterm infants.
Neonatal Research and Transport Fellow email@example.com
Andrea C Masi2
Janet E Berrington1,2
1Department of Neonatology, Newcastle upon Tyne Hospitals NHS Foundation Trust
2Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne
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