Infant Journal
for neonatal and paediatric healthcare professionals

Neonatal Research Priority Setting Partnership: help wanted

Katie Evans
Neonatal Research Priority Setting Partnership Project Co-ordinator and Clinical Research Fellow in Neonatal Medicine at Chelsea and Westminster Hospital

Chris Gale
Academic Neonatologist and Neonatal Society Meeting Secretary

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paracetamol; therapeutic drug level; patent ductus arteriosus
Key points
  1. Lower cumulative doses of IV paracetamol may be equally efficacious to higher daily cumulative doses while assuring a better safety profile.
  2. Our review casts doubt on the therapeutic drug concentration of paracetamol as a marker of its safety or efficacy.
  3. Well-designed multicentre RCTs allowing exploration of predictive kinetic behaviour of paracetamol are needed to establish its safety and efficacy over NSAIDs.

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