From “just reflux” to lissencephaly: An infant’s diagnostic journey

Diagnostic overshadowing in early infancy can delay the identification of rare congenital neurological disorders. This case highlights the clinical challenge of distinguishing atypical paroxysmal events from benign infant phenomena, the critical role of neuroimaging in unexplained neurological signs, and the multidisciplinary management required for complex cortical malformations

Dr N Abdelmahdy
Paediatric Registrar

Dr J Browne
Paediatric Consultant

Dr A Turgutogullari
Paediatric SHO

Dr A Khan
Paediatric Registrar
abdullah.khan7@nhs.net

St Peter’s Hospital, Chertsey

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Keywords

lissencephaly; neurological disorders; seizures ;

Also published in Infant:

VOLUME 9/ISSUE 6, NOVEMBER 2013

Seizures in a neonate on zidovudine prophylaxis

Infants exposed to human immunodeficiency virus (HIV) should receive postpartum antiretroviral therapy to reduce mother-to-child transmission of the virus. This report describes the occurrence of seizures in a neonate on zidovudine (azidothymidine, AZT) prophylaxis born to an HIV positive mother.