Prevention of late-onset sepsis in the neonate

The number of infants at risk of late-onset sepsis (LOS) has increased due to the improved survival of very low birthweight infants and their need for invasive monitoring and support. LOS is a cause of significant mortality and morbidity that in turn results in life-long economic consequences for society. Effective strategies to prevent LOS and regular feedback of surveillance data are associated with a progressive decrease in incidence of infection. This literature review explores such preventative strategies and the evidence for NICU care bundles in preventing LOS.