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Volume 16/Issue 5, September 2020

Bone health of extremely preterm infants: screening, monitoring and management of metabolic bone disease of prematurity

Asma Yasmeen, Allan Jackson


In this review article we summarise the pathogenesis of metabolic bone disease (MBD, also called osteopenia of prematurity). We consider the screening tools and the recommendations of professional bodies on management of MBD. We also present two case studies of long bone fractures in extremely premature infants following MBD. Based on the literature and our two cases, we propose a screening, monitoring and management algorithm for MBD of prematurity.

Neonatal units should have a screening policy for infants at risk of MBD. Development of local guidelines with multidisciplinary pathways can be helpful in management of advanced disease. Development of consensus guidelines for screening and management in the UK are required.
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